Curcumin and Breast Cancer ---
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February 20, 2018

By Susan Callahan, Associate Editor and Featured Columnist









Perhaps there is no other natural remedy that has received
as much interest from the scientific community in the past 20
years as curcumin, the spice that gives curry and tumeric
their yellow color. And for good reason. The list of cancers,
viral infections and ailments which appear to be inhibited,
relieved or in some cases reversed through use of curcumin
supplementation is extensive.

Curcumin acts to inhibit or reverse autoimmune diseases,
cardiovascular conditions, neurological conditions, and
psychological diseases, as well as diabetes and cancer,
various studies have found.

Almost all of these studies have been conducted by world-
renown scientists from universities and leading hospital
centers in the United States and elsewhere in the world.

Here is just a sample:

Against Hepatitis C: "Curcumin inhibits hepatitis C virus
replication via suppressing the Akt-SREBP-1 pathway",  
conducted by Pusan National University, Republic of Korea,
2008.

Against HIV and Aids: "Curcumin and its analogues: a
potential natural compound against HIV infection and AIDS",
conducted by The University of Texas MD Anderson Cancer
Center, Houston, Texas, 2015.

Against Various Cancers: "Curcuma as a functional food in
the control of cancer and inflammation" conducted by the
Institute of Oncology, Ziv Medical Center, Faculty of
Medicine, Zefat, Israel, 2011.

Curcumin Is an Ancient Spice

Curcumin, technically known as "diferuloyl methane", is a
hydrophobic polyphenol derived from rhizome (turmeric) of
the herb Curcuma longa.

Curcumin is an ancient spice, used for thousands of years.
Curcumin makes up about 5% of the Indian spice tumeric,
and it is in India that humans first used curcumin some
5,000 years ago in Ayurvedic medicine.

But though it was used as a part of the tumeric spice mix for
thousands of years, it was not actually isolated and named
until 1815. In that year, two French scientists, A. Vogel, Sr.,
and Pelletier published their discovery of a "yellow coloring
matter of tumeric" in the Journal de Pharmacie.

This yellow coloring matter  would go on to be studied in
more than 6000 studies and 65 clinical trials in just the past
20 years.

Over that time, scientists have learned that curcumin acts
powerfully and in a multi-directional way against multiple,
important chemical pathways in or bodies.  It appears to act
be especially active in pathways of inflammation. Why is this
important?

This is important because scientists have now come to
understand the central importance if inflammation in the
pathway of almost all significant diseases.

If inflammation were a point of geography, it would be
Grand Central Station. Cancer requires inflammation as a pre-
condition to start. Heart disease requires inflammation as a
pre-condition to start.


Curcumin is a powerful anti-inflammatory substance.
Cytokines, compunds which our bodies, inflammatory
produce in response to infection, are down regulated by
curcumin. C-reactive protein, a marker of the amount of
inflammation in your blood, is significantly lowered by
curcumin. Because of curcumin's ability to down-regulate or
inhibit inflammation, it interrupts, inhibits or prevents the
initiation or acceleration of many diseases.


Curcumin Acts Specifically Against Breast Cancer





























Cancer occurs in three phases --- initiation, growth and
proliferation. Cancer cells are "successful". They achieve
their aim of infiltrating and spreading quite well, if left alone.
To originate, then to grow, and finally to take over the
human body, cancer acts like a clever burglar, perhaps the
most clever burglar ever known. This most clever of thieves
succeeds because it knows how to pick many different kinds
of locks that the body has in place to ward off such criminals.

Cancer, in fact, succeeds by down-regulating as many as 500
different genes in your body.  This is what is so poorly
understood by most people when they speak of cancer.

The diverse talent of cancer to attack in 500 ways is the
reason that most cancer drugs are so limited in their
effectivess.  Drugs that traget only one pathway fo attack
leave open 499 others fro cancer to exploit.


But curcumin is different. Curcumin acts broadly to affect
inflammatory pathways and gene expression. We don't yet
know if curcumin can act as broadly as the 500 targets that
cancer can access but early research suggests it just may.

Curcumin inhibits the growth of breast cancer cells in many
ways. It sends breast cancer cells into an early death called
"apoptosis".

As a 2013 study from Shandong University of Technology
noted in reviewing other studies from the US: "It has been
found that curcumin inhibits the migratory activity of breast
cancer cells, proliferative rate, adhesion, and invasion
through down-regulating the expression of [nuclear factor]
NF-κBp65."

To grow, cancer cells need blood vessel system separate
from the healthy one that supplies your body. Curcumin cuts
off this supply line by inhibiting the growth of new
endothelial cells supporting the tumor. Specifically, it inhibits
a compound called "vascular endothelial growth factor
(VEGF)" in tumor cells.

Curcumin Improves the Effectiveness of Mytomycin By
Reducing Side Effects Harmful to the Kidneys and Bone
Marrow

Doctors often attack breast cancer cells using mytomycin C, a
DNA cross-linker and antineoplastic agent.

A dangerous side effect of mytomycin C is its toxicity to your
kidneys and bone marrow. In other words, mytomycin kills
the cancer cells by almost killing you too.

Here, curcumin helps too. Curcumin mitigates the toxicity of
mitomycin C  by making the cancer cells more susceptible to
mytomycin C. Curcumin also appears to help shield normal
cells from damage from mytomycin C.

To paraphrase a well-known promise "If you like your bone
marrow cells, you can keep your bone marrow cells. If you
like your kidneys, you can keep your kidneys."

Only this time, curcumin actually keeps its promise to your
body.


Curcumin Is Poorly Absorbed But Here's a Fix for That


Curcumin has low bio-availability, meaning it is poorly
absorbed. But one solution to that problem is to take it in
combination with black pepper. Piperine, the active
ingredient in black pepper, improves curcumin's bio-
availability by 2000%.



Curcumin Is Not a Substitute for Your Doctor's Prescribed
Cancer Drugs or Treatment

Many proponents of natural therapies for cancer urge that
they help you to avoid the side effects of traditional
chemotherapies or radiation. They may even suggest that
using natural terapies helps you to avoid surgery. None of
these are sound or scientifically proven approaches. They
also are dangerous.

Never substitute curcumin or any other natural remedy for a
cancer treatment plan prescribed by your doctor. Discuss
how curcumin can be used in conjunction with the
prescribed anti-cancer medical therapies, to complement or
perhaps even, as is the case with mitotycin C, to enhance
their effectiveness.

There
are also no studies yet differentiating between the
effectiveness of curcumin on Stage 1 versus later stages of
breast cancer.






























































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Curcumin inhibits growth of breast
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